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 "Diindolylmethane which is found in Brassica vegetables may assist in breast

disease associated to hormonal changes in mature women"




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Recently, researches have expressed much interest in the possible benefits of reducing the risk of developing certain types of cancers by increasing the consumption of vegetables from the Brassica family. In particular they are excited about the extraction of the concentrated constituent, Diindolylmethane responsible for this effect.

At the University of California at Berkeley, the Director of the National Institutes of Health Cancer Research Program announced the university were studying the anticancer properties of Diindolylmethane (DIM), a naturally occurring compound found in Brassica vegetables (broccoli, cauliflower, cabbage, kale, brussels sprouts), when they made a remarkable discovery.

DIM would appear to be a potent activator of the immune response system. Activation of the immune system in part explains DIM's anticancer properties, and for the first time, sheds light on its potent antiviral and antibacterial properties.


The supplement provides phytonutrients equivalent to approximately five pounds of fresh organic uncooked broccoli, tomatoes and spinach per day. All broccoli extract supplements on the market today, without exception, do not have the active ingredient of Diindolylmethane as their manufacturing process (heat or freeze drying) destroys the enzyme necessary for the production of the key phytonutrients present in this supplement.

In America Diindolylmethane has been release as a supplement under the name of ActivaMune while in Australia a company called MD Nutritionals has the licensed and markets the supplement under the name of Indolplex.

About DIM

Diindolylmethane (DIM) is a natural compound formed during the autolytic breakdown of glucobrassicin present in food plants of the Brassica genus, including broccoli, cabbage, Brussels sprouts, cauliflower and kale. The autolytic breakdown of glucobrassicin requires the catalytic reaction of the enzyme myrosinase which is endogenous to these plants and released upon rupture of the cell wall.

Solubility and Bioavailability

Diindolylmethane is a lipophilic oil-soluble compound. Similar to other oil-soluble phytochemicals, the presence of oil and other lipophilic compounds, such as phosphatidylcholine and Vitamin E, greatly increases the absorption and bioavailability of DIM upon oral administration.

Researchers at the University of California at Berkeley suggest that Diindolylmethane (DIM) may be useful in reducing the risk of such conditions as benign or cyclical breast pain, benign prostatic hyperplasia (BPH), breast cancer, cervical dysplasia, dysmenorrhea, endometriosis, fibrocystic breast disease (FBD), human papilloma virus (HPV)- associated conditions, menopause, premenstrual syndrome (PMS), sensitivity to and in conjunction with hormone replacement therapy, sexual vitality (females and males), uterine fibroids, weight management and for stimulating ketogenesis (while allowing higher carbohydrate intake).


While the research on Diindolylmethane looks promising, research on the vegetable extract is still at its early stages.

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